Reversible retinal vessel closure from VEGF-induced leukocyte plugging

Reversible retinal vessel closure from VEGF-induced leukocyte plugging.

Clinical trials in patients with macular edema due to diabetic retinopathy or retinal vein occlusion (RVO) have shown that suppression of VEGF not only improves macular edema, but also reopens closed retinal vessels, prevents progression of vessel closure, and improves retinopathy. In this study, we show the molecular basis for those clinical observations. Increased retinal levels of VEGF in mi...

Extracting Vessel Centerlines From Retinal Images Using Topographical Properties and Directional Filters

In this paper we consider the problem of blood vessel segmentation in retinal images. After enhancing the retinal image we use green channel of images for segmentation as it provides better discrimination between vessels and background. We consider the negative of retinal green channel image as a topographical surface and extract ridge points on this surface. The points with this property are l...

Vessel-widening by VEGF

A group of epithelial cells in the thymus guard against autoimmunity by presenting self-antigens to developing T cells—those T cells that take the bait are then killed. On page 1267, Rossi et al. identify the signaling pathway that creates this epithelial barrier and the cells that activate this pathway. Self-reactive T cells are eliminated when they latch on to selfantigens presented by a smal...

Vessel Junction Detection From Retinal Images

This paper presents a perceptual organization based method for detecting Vessel Junctions (VJs) from retinal images. A retinal image is first segmented into edge traces which contain vessel boundaries. Each trace is divided into generic curve segments (GCSs) at curve partitioning points (CPPs). CPPs are the places on a trace from where the continuity of GCSs was broken according to perceptual o...

Blood Vessel Segmentation from Retinal Images